Tetracaine hydrochloride

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Basic Info. 

Alias: Tetracaine hydrochloride ,2-Dimethylaminoethyl 4-n-butylaminobenzoate hydrochloride;4-(Butylamino)benzoic acid

CAS NO.: 136-47-0

EINECS: 205-248-5

MF: C15H25ClN2O2

MW: 300.82

Melting point: 149C

Assay: 99%

Grade: Pharmaceutical Grade

Storage: Closed, confined and shading preservation

Manufacturer: HUAO

Usage: Local anesthetic; Mainly used in mucosa anesthetic. The function is stronger than Procaine

and Lidocaine.




Tetracaine HCl is synthesized from 4-butylaminobenzoic acid. The ethyl ester is formed through an

acid-catalyzed esterification reaction. Base-catalyzed transesterification is achieved by boiling the ethyl

ester of 4-butylaminobenzoic acid with excess 2-dimethylaminoethanol in the presence of a small amount

of sodium ethoxide.



Tetracaine (INN, also known as amethocaine; trade name Pontocaine. Ametop and Dicaine) is a potent

local anesthetic of the ester group. It is mainly used topically in ophthalmology and as an antipruritic, and it

has been used in spinal anesthesia.

In biomedical research, tetracaine is used to alter the function of calcium release channels (ryanodine

receptors) that control the release of calcium from intracellular stores. Tetracaine is an allosteric blocker of

channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium

release events, while at high concentrations, tetracaine blocks release completely

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