- Pramoxine Hydrochloride
English Synonyms: proctofoam; Pramoxine HCL; Praxomine Hydrochloride; Tronothane Hydrochloride; ; pramocaine Hydrochloride;
EINECS Number: 211-293-1
Long Acting Local Anesthetic Drugs Pramoxine Hydrochloride / HCl CAS 637-58-1
Boiling point: 427 ° C at 760 mmHg
Flash Point: 123.5 ° C
Vapor Pressure: 1.7E-07mmHg at 25 ° C
Appearance: white or almost white crystalline powder
- Topical anesthetics are used to relieve pain and itching caused by conditions such as sunburn or
other minor burns, insect bites or stings, poison ivy, poison oak, poison sumac, and minor cuts and
scratches. Pramocaine and dibucaine are also common ingredients in
over the counter hemorrhoid preparations.
- Muscle relaxant (smooth)and slows growth of unwanted facial hair.
- Pramocaine (INN and BAN, also known as pramoxine or pramoxine HCI) is a topical anesthetic
discovered at Abbott Laboratories in 1953 and used as an antipruritic. Chemically, it is p-n
butoxyphenyl gammamorpholinopropyl ether hydrochloride. During research and development,
pramoxine hydrochloride stood out among a series of alkoxy aryl alkamine ethers as an especially
good topical local anesthetic agent.
- Pharmacologic study revealed it to be potent and of low acute and subacute toxicity, well tolerated by
most mucous membranes and of a low sensitizing index in man. Like other local anesthetics,
paramoxine decreases the permeability of neuronal membranes to sodium ions, blocking both initiation
and conduction of nerve impulses. Depolarization and repolarization of excitable neural membranes
is thus inhibited, leading to numbness.
Pramoxine Hydrochloride Fuction:
Structurally, it is the esther hydrochloride of p-n butoxyphenyl gammamorpholinopropane. The substance stood out as a good topical local anesthetic agent when Abbott Laboratories were researching a series of alkoxy aryl alkamine ethers for such an application. Pramocaine is tolerable by most mucus membranes and ranks low on the sensitizing index, making it unlikely to trigger an allergic reaction.
Surgical anesthesia:Epidural anesthesia (including epidural anesthesia during cesarean section);Local infiltration anesthesia.
Acute pain control:For postoperative or labor analgesia continuous epidural infusion can be used can also be intermittent medication;Local infiltration anesthesia.
Topical anesthetics are used to relieve pain and itching caused by conditions such as sunburn or other minor burns, insect bites or stings, poison ivy, poison oak, poison sumac, and minor cuts and scratches. Pramocaine and dibucaine are also common ingredients in over the counter hemorrhoid preparations.