- Mk-677 — Nutrobal (Mk-677)
Mk-677 — Description:
Nutrobal (MK-677) is an orally administrated growth / hormone secretagogue originally developed by Reverse Pharmacology. A secretagogue is the term for a substance that chemically signals for the pituitary gland to secrete . In other words, MK-677 could be compared to peptides like GHRP-6 or Ipamorelin, only it doesn’t require any injections nor does it have any side effects like GHRP-6. This GHS (Growth / Hormone Secretagogue) was developed in an aim to combat such conditions as muscle wasting, obesity and osteoporosis. It was also targeted towards treatment of elderly hip fracture patients, so there are a myriad of studies done on safety
Mk-677 — Benefits :
In a study on it’s effects on catabolic states, a once daily oral dose of 25mgs was given
to healthy young men subjected to short-term diet-induced nitrogen wasting. After 7 days of this dose, the subjects showed a sustained
increase in serum concentration of IGF-1 and Growth Hormone; in addition, the nitrogen wasting was reversed, showing great
potential for treatment of conditions involving muscle wasting.
Trials testing the effects of this GHS on fighting obesity showed an increase in lean
body mass, but neither total, nor visceral adipose tissue was effected. This study gave
subjects 25mgs of Nutrobal per day for 8 weeks. The subjects showed an increase in
basal metabolic rate after 2 weeks, and an increase in serum levels of GH, IGF-1 and IGF-1 binding protein-3. Increase in lean body mass was hypothesized to be caused by an increase in calorie deposition into the muscle and appetite decrease as opposed to reducing fat storage
A study done for the treatment of osteoporosis and bone mineral density showed some
increase in bone density, so there is a true impact on bone mineral density. This can
help with injury recovery during your cycle.