- Product Name:Linocaine hydrochloride
solubility H2O: soluble
Usage:used in Local anesthesia and heart rhythm disorders.
|Characteristics||A white or almost white crystalline powder||Conform|
|Identification||Should meet related requirements||Conform|
|Appearance of solution||Should meet related requirements||Passed|
|Specific optical rotation||+135°~+150°||+143°|
|Boiling point||350.8°C at 760 mmHg||Conform|
|Lincomycin B||5.0% max||2.9%|
|Heavy metals||5ppm max||Conform|
|Residue on ignition||0.5% max||0.1%|
|Bacterial endotoxins||smaller than 0.5IU/mg|
|Assay||99-101%(C14H23ClN2O, anhydrous substance)||99.5%|
Lidocaine hydrochloride is a white powder without smell and with a bitter taste that is
used both in human and veterinary medicine. The drug is also known as lignocaine
hydrochloride, and is used as a local anesthetic and to regulate certain medical
problems related to heart rhythm. Injections of it are used to provide local anesthesia
during various minor surgical procedures. It is also available in various topical
preparations, such as gels, sprays, creams, and ointments that are usually applied to
the skin or the mucous membranes. This drug was first manufactured in Sweden in
1943 and was then named xylocaine.
When used for anesthetic purposes, lidocaine hydrochloride works by blocking certain
functions of the nervous system, inhibiting the transmission of pain impulses from the
treated area to the brain. It is a fast-acting form of local anesthesia that often starts to work within five minutes. The effects
wear off in a relatively short time, often a couple of hours, because the drug is quickly
metabolized by the liver.
Lidocaine hydrochloride is used on the skin to stop itching and pain from certain skin
conditions (e. G., scrapes, minor burns, eczema, insect bites) and to treat minor
discomfort and itching caused by hemorrhoids and certain other problems of the
genital/anal area (e. G., anal fissures, itching around the vagina/rectum). Some forms
of this medication are also used to decrease discomfort or pain during certain
medical procedures/exams (e. G., sigmoidoscopy, cystoscopy). Lidocaine is a local
anesthetic that works by causing temporary numbness/loss of feeling in the skin and
Proparacaine hydrochloride and tetracaine are also indicated to produce local
anesthesia prior to surgical procedures such as cataract extraction and pterygium
excision, usually as an adjunct to locally injected anesthetics.
Ophthalmic solutions used for intraocular procedures should be preservative-free. Preservatives may cause damage to the corneal epithelium if a significant
quantity of solutionenters the eye through the incision.