- SARMS Raw Powder 317318 – 84 – 6 GW0742
GW0742 — Quick Details:
GW0742 — Product Name: GW0742
GW0742 — Synonyms: GW0742;;4-[2-(3-FLUORO-4-TRIFLUOROMETHYL-PHENYL)-4-METHYL-THIAZOL-5-YLMETHYLSULFANYL]-2-METHYL-PHENOXY-ACETIC ACID;4-[[[2-[3-Fluoro-4-(trifluoromethyl)phenyl]-4-methyl-5-thiazolyl]methyl]thio]-2-methylphenoxy]AceticAcid;4-[2-(3-Fluoro-4-trifluoromethyl-phenyl)-4-methyl-thiazol-5-ylmethylsulfanyl]- 2-methyl-phenoxy}-acetic acidenoxy);GW 0742X
GW0742 — CAS: 317318-84-6
GW0742 — MF: C21H17F4NO3S2
SARMS Raw Powder GW0742 CAS: 317318-84-6 Light Yellow Solid
GW0742 — MW: 471.49
GW0742 — mp 134.5-135.5 °C
GW0742 — storage temp. 2-8°C
GW0742 — solubility DMSO: >5 mg/mL
fGW0742 — Form : solid
GW0742 — color : white
GW0742 — Chemical Properties Light Yellow Solid
GW0742 — Usage:
Usage A small molecule agonist of the human Peroxisome Proliferator-Activated Recept d (PPAR d). It shows an EC50 of 1.1 nM against PPAR d with 100-fold selectivity over the other human subtypes
Usage A small molecule agonist of the human Peroxisome Proliferator-Activated Recept δ (PPAR δ). It shows an EC50 of 1.1 nM against PPAR δ with
100-fold selectivity over the other human subtypes.
GW0742 (also known as GW610742) is a PPARδ/β agonist that is investigated for drug use by GlaxoSmithKline.
GW0742 — Description:
A high throughput screening campaign was conducted to identify small molecules with
the ability to inhibit the interaction between the vitamin D receptor (VDR) and steroid
receptor coactivator 2. These inhibitors represent novel molecular probes to modulate
gene regulation mediated by VDR. The peroxisome proliferator-activated receptor δ (PPARδ) agonist GW0742 was among the identified VDR-coactivator inhibitors and has been characterized herein as a pan nuclear receptor
antagonist at concentrations higher than 12.1 µM. The highest antagonist activity for
GW0742 was found for VDR and the androgen receptor (AR). Surprisingly, GW0742
behaved as PPAR agonist/antagonist activating transcription at lower concentration
and inhibiting this effect at higher concentrations.
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