- English name: 4-Acetamidophenol
English Name: Acetaminophen; 4-Hydroxyacetanilide; Paracetamol; APAP; p-Hydroxyacetanilide; 4-Acetamino phenol; Acetaminphen; Paracetamol DC; N-Acetyl-4-aminophenol; N- (4-hydroxyphenyl) acetamide; Acetamiophen
EINECS Number: 203-157-5
Melting point: 168-172 ℃
Water-soluble: 14 g / L (20 ℃)
Melting point 168-172 ° C
Water-soluble 14 g / L (20 ° C)
Appearance: White crystalline powder
4-Acetamidophenol-Chemical Properties and Usage:
Chemical Properties White Solid
Usage dispersing agent in liquid scintillation counting
Usage Analgesic; antipyretic
General Description Odorless white crystalline solid. Bitter taste. pH (saturated aqueous solution) about 6.
Air & Water Reactions Slightly soluble in water.
Reactivity Profile 4-Acetamidophenol is sensitive to light. Incompatible with strong oxidizers. .
Fire Hazard Flash point data for 4-Acetamidophenol are not available; however, 4-Acetamidophenol is probably combustible.
Biological Activity Cyclooxygenase inhibitor; may be selective for COX-3 (IC 50 values are 460, > 1000 and > 1000 μ M for canine COX-3, and murine COX-1 and COX-2 respectively). Widely used analgesic and antipyretic agent. .
Paracetamol is used for reducing fever in people of all ages. The World Health Organization (WHO) recommends that paracetamol be used to treat fever in children only if their temperature is greater than 38.5 °C (101.3 °F).The efficacy of paracetamol by itself in children with fevers has been questioned and a meta-analysis showed that it is less effective than ibuprofen.
Paracetamol is used for the relief of pain.
The American College of Rheumatology recommends paracetamol as one of several treatment options for people with arthritis pain of the hip, hand, or knee that does not improve with exercise and weight loss. A 2015 review; however, found it provided only a small benefit in osteoarthritis.
Paracetamol has relatively little anti-inflammatory activity, unlike other common analgesics such as the NSAIDs aspirin and ibuprofen, but ibuprofen and paracetamol have similar effects in the treatment of headache. Paracetamol can relieve pain in mild arthritis, but has no effect on the underlying inflammation, redness, and swelling of the joint. It has analgesic properties comparable to those of aspirin, while its anti-inflammatory effects are weaker. It is better tolerated than aspirin due to concerns with bleeding with aspirin.
Low back pain
Based on a systematic review, paracetamol is recommended by the American College of Physicians and the American Pain Society as a first line treatment for low back pain.However other systematic reviews concluded that evidence for its efficacy is lacking.